Venom of Orthochirus Scrobiculosus

Venom of Orthochirus Scrobiculosus

 

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Available for sale here is Venom of Orthochirus Scrobiculosus :

The venom of Orthochirus scrobiculosus, a Central Asian scorpion, is a potent source of bioactive peptides, specifically targeting potassium channels with high affinity, such as OSK1 and OSK3. The venom is studied for its neurotoxic components, including toxins that block channels (relevant for immunosuppression) and insecticidal proteins.

These small to medium-sized buthids typically measure 22–55 mm in adult length and are characterized by distinctive morphological traits, including a strongly trapezoidal carapace with five pairs of lateral eyes, a beta-configuration of dorsal trichobothria on the pedipalp femur, and an elongate telson lacking a subaculear tubercle.

Key aspects of Orthochirus scrobiculosus venom include:
OSK1 Toxin: A 38-residue peptide containing three disulfide bridges, OSK1 is highly positively charged. It is a potent blocker of voltage-gated potassium channels.
Pharmacological Potential: Due to their high affinity for potassium channels, specifically , these toxins are researched for their potential in developing immunosuppressive drugs.

Insect Specificity: The venom contains components like OsI-1, which are specifically active against insects.
Structural Studies: Researchers have performed extensive structure-function studies on OSK1, including creating analogs with modified residues (e.g., [Lys16, Asp20]-OSK1) to enhance or alter target selectivity.

OSK3, from the venom of the scorpion Orthochirus scrobiculosus, is a potassium channel blocker that belongs to the α-KTx8 subfamily and targets the voltage-gated potassium channels.

OSK3 is secreted from the venom gland of Orthochirus scrobiculosus, which is also known as the Central Asian scorpion and belongs to the Buthoidea superfamily, the largest scorpion superfamily.

The toxin gets its name from the acronym of the species it originates from, the type of ion channel it blocks, and the order of its discovery within the toxin family.

Product ID: L2117
Name: Orthochirus scrobiculosus
Common Name(s): Central asian scorpion
Origin: Central Asia
Purity: >99%
Form: Lyophilized powder
Packaging: In vacuum sealed glass vials, in secured parcel.

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